"We should accept that most research findings will be refuted. Some will be replicated and validated. The replication process is more important than the first discovery," Ioannidis says.

Seems to me that this is the heart and soul of the scientific method, and even though 50%+ of all findings might be "false", the SCOPE of error is continually reduced, while the scope of "known" is increased.

Take the example of a simple binary search - I can quickly determine a value between 1 and 100 by testing with a number in the middle, as long as I know whether my last guess was too high or too low.

I guess 50 - you say too high.
I guess 25 - you say too low.
....

won't take long to get your number, but all my guesses except the last are wrong!

Peski
"Marge, don’t discourage the boy! Weaseling out of something is important to learn. It’s what separates us from the animals. Except the weasel." - Homer Simpson